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PLURIPOTENT STEM CELLEmergence of New Stem Cell: Induced Pluripotent Stem Cell

Development toward cell therapy, disease Modeling, and drug discovery.

human pluripotent stem cells (hPSCs), which include human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs), have emerged as promising candidates for cell therapy since they have clear target cell differentiation capacity as well as paracrine effects. Advances in the technologies of hiPSC generation without viruses have heightened the expectations for its clinical use.

ENDOTHELIAL CELLBarriers for Developing hiPSC-EC as Cell Therapy

Elimination of Animal-derived Elements

Fully defined, xenogeneic ingredient-free methods.

Universality

High efficiency and standardization of protocol. Reduced production cost and commercialization.

Generation of high purity ECs

We developed unique system to yield highly purified ECs.

Tumorigenicity and Aberrant Differentiation

Highly pure differentiated ECs lack of aberrant tissue or tumor development.

hiPSC-ECClinically Compatible hiPSC-ECs

Differentiation of ECs from hiPSCs via clinically compatible manner.

Human iPSCs and hiPSC-ECs are generated to ensure the safety of the products and expedite the time for clinical transition. This product has conceptual, technological, scientific and clinical novelty.

We have developed a unique system to differentiate hPSCs into highly purified functional ECs for clinical use including:

  • hiPSC generation without viruses
  • Fully defined, xenogeneic ingredient-free method
  • High efficiency and standardization of protocol / Universality
  • Generation of high purity ECs
  • No Tumorigenicity and Aberrant Differentiation

NEW BLOOD VESSEL FORMATIONRobust Vessel-Forming Activities of hiPSC-ECs

hiPSC-ECs are effective for promoting recovery from ischemia and inducing organ regeneration

We developed a differentiation system to produce hPSC-ECs to improve the efficiency of differentiation and demonstrated a direct vascular-incorporation of hPSC-ECs into blood vessels in animal models.

Favorable effects of hiPSC-ECs on recovery in:

  • Hindlimb ischemia in mice
  • Blood flow
  • Limb loss index
  • Vascular Density

Our Mission is to Develop Innovative Cell Therapy for Cardiovascular Disease

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Our Target Disease

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Peripheral Artery Occlusive Disease (PAOD/PAD)
Critical Limb Ischemia (CLI)
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Coronary Artery Occlusive Disease (CAOD/CAD)
Myocardial Infarction (MI)
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Diabetic Peripheral Neuropathy (DPN) / Intractable Wound / Pressure Ulcer