The goal of his research is to develop a strategy for regenerating cardiovascular diseases using stem cells and tissue engineering technologies. Dr. Yoon has focused on generating stem cells including induced pluripotent stem cells, multipotent bone marrow cells, and directly reprogrammed cells, and developing various methods to differentiate these cells into endothelial cells.
He investigates their therapeutic utility in cardiovascular diseases such as peripheral vascular disease including diabetic complications, myocardial infarction, lymphedema and diabetic neuropathy. Mechanistically, the research focuses on angiogenesis, vasculogenesis, lymphangiogenesis and cardiomyogenesis. Recently, his research is extended into bioengineering of stem cells, reprogramming of somatic cells into target cells and restoring the function of damaged stem or progenitor cells by epigenetic modifications.
Young-Sup Yoon, MD, PhD